![]() ![]() ![]() This enhanced nutrient availability supports higher protein synthesis rates, leading to increased yields of the desired vaccine antigens.Įnabling Scale-Up and Process OptimizationĪs mRNA vaccine candidates progress through preclinical and clinical development, the need for large-scale production becomes paramount. The shaking motion helps to overcome mass transfer limitations, ensuring uniform distribution of nutrients and oxygen throughout the cell culture. Incubator shakers aid in optimizing protein expression by providing a controlled environment that facilitates the translation of mRNA into proteins. Once mRNA molecules are successfully transfected into cells, the next step is to ensure efficient protein expression. This improved transfection efficiency translates into higher yields of mRNA-transfected cells, which are essential for subsequent stages of vaccine development and testing. The shaking motion creates gentle agitation, helping to improve the contact between mRNA molecules and cell membranes, thereby facilitating higher uptake rates. Incubator shakers play a crucial role in improving transfection efficiency by enhancing the delivery of mRNA molecules into cells. Transfection, the process of introducing mRNA molecules into cells, is a vital step in mRNA vaccine development. This level of control not only enhances the yield and purity of mRNA but also reduces the likelihood of experimental variability, increasing the reliability of results. ![]() They maintain precise temperature, humidity and agitation levels, allowing cells to thrive and efficiently carry out the protein synthesis process. Incubation shakers are specialized instruments designed to create optimal growth conditions and controlled environments for cultures ensuring that mRNA molecules are efficiently translated into proteins. The research and development of mRNA technologies rely heavily on the use of advanced laboratory equipment, with incubation shakers playing a crucial role as the “universal workhorse” of mRNA-based therapy development. To facilitate the development and production of mRNA vaccines, it is essential to have advanced laboratory equipment that meets the stringent requirements of this specialized field.Īddressing the Unique Challenges of mRNA Vaccine Development After the battle against the pandemic, the field of cancer therapies is now in the focus of research, where mRNA is a very promising approach. This method has proven immensely successful in the development of COVID-19 vaccines, enabling rapid response and deployment. Once inside our cells, this mRNA is translated into the viral protein, triggering an immune response without causing the actual infection. However, mRNA vaccines take a different approach by delivering a small piece of synthetic mRNA that encodes a viral protein. Traditional vaccines often involve introducing weakened or inactivated pathogens to stimulate an immune response. The new design comes with an Ethernet interface that can be used for connecting to our bioprocess software platform eve®, which communicates with your Scada system.At the heart of mRNA technology lies the ability to develop vaccines and therapeutics that work in harmony with our own immune systems. A condensate-free direct-steam humidificationīy combining our bioprocess expertise with new technologies, the new Multitron is a response to trends and to new demands in research and development, including digitalization.The hygienic design of the new Multitron has been improved rounded interior corners and a chamber with fewer components, making it far easier to clean.The new temperature-control concept allows users to achieve optimum, gradient-free temperature uniformity, guaranteeing comparable growth conditions across all batches.The new door mechanism and quick automated start-stop feature keep interruptions in the cultivation process to a minimum.The top unit remains at a comfortable working height of 1.40 m. The capacity-to-footprint ratio is unlike any other: by using a three stack, researchers can cultivate over 60 liters or 23,000 batches in parallel, with a base of only 1 m wide. The Multitron meets the stringent requirements of cell-culture applications and satisfies the increasing efficiency demands of the biotech industry. It delivers unsurpassed capacity on a minimal footprint with easy operation. The new Multitron offers researchers even better conditions for cultivating microorganisms, cell cultures and phototropic organisms. ![]() A new chapter in an ongoing success story: over 20 years after the Multitron was first introduced on the market, Infors HT now presents its redesigned incubation shaker. ![]()
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